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At just 18 years old, Loren was involved in a catastrophic forklift accident; to save his life, doctors cut him in half; Sofia was an active 29-year-old when her heart went into end-stage failure; now she must be plugged-in to stay alive.
Tiffany has progeria, a condition that causes her to age rapidly, yet she's already outlived her life expectancy; single dad Ryan was born with arthrogryposis, leaving his arms and legs fused.
Lukas has Parry-Romberg Syndrome, causing half his face to shrink inward; Stefani's rare muscular dystrophy leaves her dependent on her mother but craving independence; Ellie says steroid withdrawal left her with lizard skin and seeks a cure.
An allergic reaction left Kirtus with vitiligo, alopecia, and bone loss.
There are only two foods that won't send Caroline into anaphylaxis; touching almost anything causes Ariana's butterfly skin to blister and tear; Aleazia's cystic hygroma caused his jaw and tongue to swell, permanently freezing his mouth open.