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Spike is sent to obedience school, leaving Jerry without a protector; Tom is ordered not to wake the Witch sisters, but Jerry wants to get the cat in trouble.
Tom is under strict orders to never sleep on Ginger's fancy mattress, but Butch convinces him to try it out; Tom and Jerry get a taste of the outdoors on their camping trip to Yosemite.
Spike forces Tom and Jerry to take over Tyke's birthday party; Tom and Jerry protect Toodles against a threat.
When it appears Spike has developed an allergic reaction to Tom, Rick buys Ginger a hypoallergenic cat named Glory; Dr. Bigby creates cookies that can give animals superpowers.
Tom and Spike have to go to the vet and Ginger hires an exterminator to take care of Jerry and Tuffy once and for all; Tom and Jerry have to go retrieve an ingredient for the witches' spell before sundown.
Tom kicks Spike's beloved chew toy over the fence and has to get it back when he sees how heartbroken Spike becomes; Butch and a squirrel detective have set up shop and are stealing Tom and Jerry's clients.
When Rick and Ginger leave Tom home alone, Tom and Jerry decide to invite their lady friends, Toodles and Toots, over for a romantic dinner; Dr. Bigby works on creating a formula for a love potion, which accidentally gets on Jerry.
Jerry and Tuffy are getting ready to go to a family reunion, and they're mailing themselves off; Tom and Jerry are hired by a bad magician to find out where his pigeon friend disappeared during a magic trick gone wrong.
Tom and Butch compete for the Golden Fez and a chance to be the top cat in the United Mouse Catchers; Hildie and Beatie commemorate the passing of their mother; Tom tries to help out by bringing her back from the grave.
Tom chases Jerry in an airplane, but Spike is in the chaos; after arriving in Hawaii, Rick and Ginger sneak Tom and Spike inside a resort that doesn't allow pets.
Tom finds a magic mirror that lets him predict the future; Spike decides to hire some detectives to find his missing bone collection.
Ginger's wedding ring falls down the drain; Tom, Jerry and Spike have to get it back.
Believing they are going to run out of food during a snowstorm, the pets start hoarding food; Jerry and Napoleon play around with Bigby's brand-new antigravity machine until Tom breaks into the lab and a chase begins.
Dutch's ruby is missing; Tom eats bad cheese and hallucinates.