Spike is sent to obedience school, leaving Jerry without a protector; Tom is ordered not to wake the Witch sisters, but Jerry wants to get the cat in trouble.
When Jerry ventures out of his hole for a late-night snack, Tom has a trap set for him; Tom falls into his own trap; Tom and Jerry are hired by Polly the Dog to get back her collar from mean guy Barkley.
Ginger is in charge of taking care of her mother's bird; Tom tries his hardest to keep from eating the bird but can't control himself; Jerry pretends to be a vampire to scare Tom who tries to keep vampire Jerry at bay.
Tom and Spike have to go to the vet and Ginger hires an exterminator to take care of Jerry and Tuffy once and for all; Tom and Jerry have to go retrieve an ingredient for the witches' spell before sundown.
When Rick and Ginger leave Tom home alone, Tom and Jerry decide to invite their lady friends, Toodles and Toots, over for a romantic dinner; Dr. Bigby works on creating a formula for a love potion, which accidentally gets on Jerry.
Tom stars in a documentary that mischaracterizes his daily activities; Dr. Bigby invents a transporting machine that accidentally transports Jerry and Tom to Paris.
Inside a cruise ship, Tom, Jerry, Tuffy and Spike encounter Meathead; Tom and Spike go on a road trip with their owners.
Tom witnesses what he believes is the kidnapping of Misty, the cute cat across the street; Hildie and Beatie threaten to get a real witch's cat, a black cat.
Believing they are going to run out of food during a snowstorm, the pets start hoarding food; Jerry and Napoleon play around with Bigby's brand-new anti-gravity machine until Tom breaks into the lab and a chase begins.
Tom's dreams of rest and relaxation end when the witches' ghost nephew Grayson comes over; Bigby invents the Asteroid Buster Elite.
Dutch's ruby is missing; Tom eats bad cheese and hallucinates.