In programme 2 the children turn four and their families face tough choices about the future. Shelbie is dangerously ill with a chromosome condition that affects her breathing. She has frequent convulsions and is in and out of hospital. Now doctors have started to question her quality of life and her mum has to decide whether it’s worth giving her further medical treatment. William has the genetic disease tuberose sclerosis, and has had major brain surgery to remove tumors on his brain. Now his